Our body consists of billions of cells that all work together. Stem cells are essential for the maintenance of our organs and tissues: they continually spawn normal cells to replace those lost, damaged, or worn out. Unfortunately, stem cell activity declines with age, leaving the body less able to repair itself.
But recently, scientists have learned that aging cells bear only part of the blame for this downward spiral. And a new study shows that it might be possible to slow the decline of aging tissue – and even make it act younger – by focusing on the stuff that surrounds those cells.
In an independent study at the University of Michigan Medical School, researchers injected the skin of 21 volunteers in their 80s with a cross-linked hyaluronic acid, often used cosmetically to reduce facial wrinkles. This filler bolsters the dermal extracellular matrix (ECM), filling in the spaces left by aging.
The ECM provides strength and resiliency to skin. The ECM consists mostly of type I collagen fibrils, which are produced by fibroblasts. Over time, as skin ages, the ECM becomes fragmented, which causes cells to lose their connections to that scaffold – and the lack of support accelerates their decline further. The scientists from U-M’s Department of Dermatology reported that these age-related alterations are largely reversed by enhancing the structural support of the ECM.
The researchers did not receive funding from the product’s manufacturer, nor did they get input on the design or results from the company. Rather, they were using the product as a way to increase the mechanical forces within the volunteers’ skin.
The study shows that injections with hyaluronic acid may actually be capable of restoring the skin. But instead of being used as a filler, as is commonly done, these molecules seem actually involved with repair, by switching on the fibroblasts which basically stimulates the body’s own collagen production. This may lead to a fairly natural form of skin repair, as opposed to artificially filling things up.
The result: over three months, the fibroblasts began expressing collagen-related genes, producing more collagen, and connecting better to the ECM. The entire layer of skin grew thicker, and more blood vessels, which nourished the cells were seen.
[quote_box author=”Gary Fisher, Ph.D.,” profession=”the Harry Helfman Professor of Molecular Dermatology and senior author of the study”]Fragmentation of the extracellular matrix plays an important role in skin aging, but by altering the matrix using an external filler and increasing the internal pressure, we’ve shown that we can essentially trigger a signal for cells to wake up.[/quote_box]
It is identical to the way in which the RG-CELL works. Injectable Hyaluronic Acid has achieved Super Star Status as a dermal filling agent. But the topical form also has amazing properties including, skin structural support which makes the skin look softer and fuller. Due to RG-Cells patented double layer delivery technology this agent is released at the deep epidermal and dermal level in many ways mimicking the action of injectable agents with daily use.
Hyaluronic Acid in the Skin
[frame src=”https://rg-cell.com/wp-content/uploads/2013/05/HyaluronicAcid_.jpg” link=”” target=”_self” width=”250″ height=”186″ alt=”Hyaluronic Acid” align=”right” prettyphoto=”false”]Hyaluronic Acid is found naturally in most every cell in the body and occurs in high concentrations in specific body locations. In each body location, it serves a different function. The skin is the largest organ in the body comprising about 15% of the body weight. Roughly 50% of the Hyaluronic Acid in our body is found in the skin. Hyaluronic Acid and Collagen are vital to maintaining the skin’s layers and structure. Unfortunately, Hyaluronic Acid also has a half-life (the time it takes for the molecule to get broken down and excreted from the body) of less than 3 days and possibly even as little as one day in the skin. For this reason, it is imperative that the body continually replenish itself with Hyaluronic Acid.
Hyaluronic Acid ‘s roles in the ECM is to help the stretchy fibers in the body from overstretching and drying out by continually bathing them in this nutritious water base gelatinous fluid. It also serves as a wonderful medium through which nutrients and waste are transported to and from the cells of these structures.
However, as we age, our cells may lose the power to produce this Acid, which in due course, leads to improper hydration. As a result, the skin gets parched and brittle. This forms lines and wrinkles with the passing of time.
The most effective anti-aging formulas contain Hyaluronic Acid. Manufacturers have created the formula based on the natural mechanism of the skin. That’s why the creams and serums are able to revitalize skin in an excellent way.
The study was designed, performed, analyzed, interpreted, and reported without involvement from the skin care manufacturers. The National Institute on Aging, part of the National Institutes of Health, supported the work.
Reference: Journal of Investigative Dermatology 133, 658-667 (March 2013) | doi:10.1038/jid.2012.364
Enhancing Structural Support of the Dermal Microenvironment Activates Fibroblasts, Endothelial Cells, and Keratinocytes in Aged Human Skin In Vivo
Taihao Quan, Frank Wang, Yuan Shao, Laure Rittié, Wei Xia, Jeffrey S Orringer, John J Voorhees and Gary J Fisher